Vaccine Sarcomas - Cats

A letter to the editor published in the Journal of the American Veterinary Medical Association in October 1991 first raised the issue of a potential association between vaccination of cats for rabies and development of sarcomas. At about this same time, the vaccine industry had shifted from production of modified-live virus vaccines for rabies prophylaxis to killed-virus vaccines. This change had been encouraged by the USDA-Animal Plant Health Inspection Service (APHIS) primarily because of concerns about vaccine-induced disease with the use of modified-live rabies virus vaccines. Most killed-virus vaccines contain adjuvants to enhance the immune response, and injection of some killed-virus vaccines has been shown to result in inflammatory granulomas in cats.2 Some of these inflammatory granulomas to progress to sarcomas.read the entire article.

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